Discovered in the 1950s, Palmitoylethanolamide or for little PEA is a fatty acid that made researchers fascinate due to its distinctive properties of natural anti-inflammatory and a pain killer. Over to the recent factions of science, this is grouped under endogenous fatty acid amides. It is a natural compound which is synthesized in mammalian cells, human cells as well as plant cells. Its molecule is deemed to have protective, reparative and most commonly anti-inflammatory functions.
After 25 years of discovery, the scientific community took it seriously because the mechanism of action was unknown and very difficult to understand. Demonstrated to activate the cell nucleus receptor, the name of Palmitoylethanolamide performs a great variety of biological functions related to chronic and neuropathic pain and inflammation as included by clinical trials. Probably because PEA is an endogenous modulator as well as a compound in food, such as eggs and milk, no serious side effects have been medically reported or had prone to have drug to drug interactions.
What to Know More
Having attracted the attention of the medical community back in 1957, with its isolation from soybeans, peanuts, and egg yolk, PEA was produced in demand for anti-inflammatory activities as the compound was critical for both innate and adaptive immunity. These actions were found to be modified via the mast cells, having an analgesic effect in several animal models.
This remarkable compound is now available as a supplement, instrumental for treating many patients all around the world. Devoid of any causal side-effects, its efficacies have made successful treatment of the following health problems such as –
- Peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome.
- Body pains like sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome.
- Dental pains, neuropathic pain in stroke, and multiple sclerosis.
- Chronic pelvic pain, postherpetic neuralgia, and vaginal pains.
- Intestinal inflammation, chronic migraine, cerebral ischemia.
An increase in PEA local levels is unquestionably considered to play protective and pro-homeostatic roles. PEA also exerts complex biological responses to harmful stimuli while producing an anti-hyperalgesic effect in various animals of inflammation and pain.
Growing insight into the function of this agent found its relationship between anandamide and investigations were made into their capacity to modulate pain sensitivity and inflammation. Further studies emerged to find out that PEA could alleviate, in a proper dose-dependent manner, pain behaviors elicited in mouse pain models and downregulate mast cell hyperactivity.
It is a member of the extended endocannabinoid family and ligands at non-cannabinoid peroxisome proliferator-activated receptors. Scientists believe due to such a lineage of this fatty acid. It like pyrroloquinoline quinone supplement may boost natural cannabinoids and protect the nerve system. Some of the solid evidence back up its health benefits. Available in tablet, capsule and powder form, it might support brain, health and immune health, but as studies have not yet appropriately encapsulated, PEA still does not fall under the category of “natural supplements”.